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Index / Biovis / Caspase-3, rat recombinant Rat /Product Detail : 1283-100 Caspase-3, rat recombinant Rat
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#1283-100 Caspase-3, rat recombinant Rat

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  Price : 373   EUR
423   USD
289   GBP
1568   Zloty
49955   JPY
2879   NOK
3085   SEK
422   CHF

Product name : Caspase-3, rat recombinant Rat

Catalog number : 1283-100

Quantity: 100 units

Availability: Yes

Supplier name : Biovis

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About this Product :

Caspase-3, rat recombinant Rat recombinant proteins Most stable storage is at - 81 C or lower but some lyophilised proteins can be stored at +4C. Please read carefully the data sheet of the Caspase-3, rat recombinant Rat.
http://mybiofast.com/ver.php?search=rec.&submit=Search

More Details about

Alternate Names / Synonyms: Active Rat Caspase-3, Caspase-3 Enzyme, caspase-3, rat caspase-3, rat caspases, active caspases, caspase-3 assay positive control

Source: E. coli

Appearance: Lyophilized powder

Physical Form Description: Lyophilized powder

Molecular Weight: large (17 kD) and small (11 kD) subunits

Purity by SDS-PAGE: N/A

Purity by HPLC: N/A

Endotoxin Level: N/A

Biological Activity: 300,000 units/mg

Reconstitution Instructions: Reconstitute to 1 unit per µl in PBS containing 15% glycerol.

Storage Temp.: -70°C

Shipping: dry ice

Background Information: Caspase-3 (also know as CPP32, Yama and apopain) is a major member of the caspase-family of cysteine proteases. Caspase-3 exists in cells as an inactive 32 kDa proenzyme. During apoptosis procaspase-3 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases, such as caspase-6 (Mch2), caspase-8 (Flice) and grazyme B. The processed form of caspase-3 consists of large (17 kD) and small (11 kD) subunits which associate to form the active enzyme. The active caspase-3 has been shown involving in the proteolysis of several important molecules, such as poly (ADP-ribose) polymerase (PARP), the sterol regulatory element binding proteins (SREBPs), focal adhesion kinase (FAK), and others. The recombinant active human caspase-3 expressed in E. coli spontaneously undergoes autoprocessing to yield subunits characteristic of the native enzyme. The active caspase-3 preferentially cleaves caspase-3 substrates (e.g., DEVD-AFC or DEVD-pNA) and is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-DEVD-pNA (Cat. #1008-200) or Ac-DEVD-AFC (1007-200).

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans.

 

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Pathways :
WP100: Glutathione metabolism
WP1039: Glutathione metabolism
WP104: Alanine and aspartate metabolism
WP106: Alanine and aspartate metabolism
WP1126: Tryptophan metabolism
WP1322: IL-6 Signaling Pathway
WP1346: IL-7 Signaling Pathway
WP1349: Wnt Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP1361: Mismatch repair
WP1379: Diurnally regulated genes with circadian orthologs
WP1388: Glycogen Metabolism
WP153: Urea cycle and metabolism of amino groups
WP1530: miRNA regulation of DNA Damage Response
WP1545: miRNAs involved in DDR
WP1631: Biotin metabolism
WP164: Glutathione metabolism
WP1965: VEGF-receptor Signal Transduction
WP2085: miRNAs involved in DDR
WP2087: miRNA regulation of DNA Damage Response
WP2287: Male mating
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP2349: vitamin B3 (niacin), NAD and NADP biosynthesis pathway
WP2353: vitamin B9 (folate) biosynthesis pathway
WP2359: Parkin-Ubiquitin Proteasomal System pathway

Related Genes :
[] Major urinary protein (MUP) (Allergen Rat n I) (Alpha(2)-euglobulin) (Alpha-2u-globulin) (alpha-2u globulin PGCL1) (allergen Rat n 1) [Cleaved into: 15.5 kDa fatty acid-binding protein (15.5 kDa FABP)]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Casp2 Ich1] Caspase-2 (CASP-2) (EC 3.4.22.55) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[Cacna1d Cach3 Cacn4 Cacnl1a2 Cchl1a2] Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Rat brain class D) (RBD) (Voltage-gated calcium channel subunit alpha Cav1.3)
[Cacna1a Cach4 Cacn3 Cacnl1a4] Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Brain calcium channel I) (BI) (Calcium channel, L type, alpha-1 polypeptide, isoform 4) (Rat brain class A) (RBA-I) (Voltage-gated calcium channel subunit alpha Cav2.1)
[Casp8] Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[Casp1 Il1bc Il1bce] Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
[Casp6 Mch2] Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
[Cacna1c Cach2 Cacn2 Cacnl1a1 Cchl1a1] Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Rat brain class C) (RBC) (Voltage-gated calcium channel subunit alpha Cav1.2)
[Plpp3 Lpp3 Ppap2b] Phospholipid phosphatase 3 (EC 3.1.3.4) (Differentially expressed in rat intestine 42) (Dri42) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b)
[Casp12] Caspase-12 (CASP-12) (EC 3.4.22.-)
[Ehmt2 Apom Bat4 Bat8 C2 C4a Cfb Csnk2b G7e Hspa1a Hspa1b Hspa1l Ly6g5c Ly6g6c Neu1 Ng35 Rps25-ps2 Stk19] Euchromatic histone lysine methyltransferase 2 (HLA-B associated transcript 8, rat orthologue)
[Casp9 RNCASP9 rCG_30964] Caspase 9, isoform CRA_a (Caspase-9) (Caspase-9 long isoform)
[Adgrg2 Gpr64 Re6] Adhesion G-protein coupled receptor G2 (G-protein coupled receptor 64) (Rat epididymis-specific protein 6) (Re6)
[Tmprss11d Rat] Transmembrane protease serine 11D (EC 3.4.21.-) (Adrenal secretory serine protease) (AsP) (Airway trypsin-like protease) (AT) [Cleaved into: Transmembrane protease serine 11D non-catalytic chain; Transmembrane protease serine 11D catalytic chain]
[Card9] Caspase recruitment domain-containing protein 9 (rCARD9)
[Xiap Api3 Birc4] E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (rIAP-3) (rIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
[App] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
[Ncdn] Neurochondrin (Neurite outgrowth-related protein from the rat brain) (Norbin)
[Stk3 Mst2] Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]
[Nol3 Arc] Nucleolar protein 3 (Apoptosis repressor with CARD)
[Stk24 Mst3 Stk3] Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (MST3b) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 35 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)]
[Cldn3] Claudin-3 (Rat ventral prostate.1 protein) (RVP1)
[Hao2 Hao3 Haox2] Hydroxyacid oxidase 2 (HAOX2) (EC 1.1.3.15) ((S)-2-hydroxy-acid oxidase, peroxisomal) (Long chain alpha-hydroxy acid oxidase) (Long-chain L-2-hydroxy acid oxidase)
[Axl axl] Rat Axl longform
[Acsl3 Acs3 Facl3] Long-chain-fatty-acid--CoA ligase 3 (EC 6.2.1.3) (Brain acyl-CoA synthetase II) (Long-chain acyl-CoA synthetase 3) (LACS 3)
[Dapk3 Zipk] Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (ZIP-kinase)
[Pde4a] cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.53) (DPDE2)
[Impa1 Imp] Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (D-galactose 1-phosphate phosphatase) (EC 3.1.3.94) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1)
[Dbnl Sh3p7] Drebrin-like protein (Actin-binding protein 1) (Abp1) (SH3 domain-containing protein 7)

Bibliography :
[29763685] Autophagy plays a pro-survival role against methamphetamine-induced apoptosis in H9C2 cells.
[28640008] Brain-derived neurotrophic factor propeptide inhibits proliferation and induces apoptosis in C6 glioma cells.
[28639431] Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia.
[27746341] Growth hormone is protective against acute methadone-induced toxicity by modulating the NMDA receptor complex.
[27310873] BDNF pro-peptide regulates dendritic spines via caspase-3.
[27233218] Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson's disease.
[26953231] Tumor necrosis factor-inducible gene 6 protein: A novel neuroprotective factor against inflammation-induced developmental brain injury.
[26687435] The recombinant C-terminal fragment of tetanus toxin protects against cholinotoxicity by intraseptal injection of β-amyloid peptide (25-35) in rats.
[26488543] TGF-β improves myocardial function and prevents apoptosis induced by anoxia-reoxygenation, through the reduction of endoplasmic reticulum stress.
[26456506] Bcl-2 silencing attenuates hypoxia-induced apoptosis resistance in pulmonary microvascular endothelial cells.