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Index / Biovis / Caspase-4, human recombinant CASP4 Human /Product Detail : 1084-25 Caspase-4, human recombinant CASP4 Human
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#1084-25 Caspase-4, human recombinant CASP4 Human

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  Price : 241   EUR
274   USD
187   GBP
1015   Zloty
32349   JPY
1864   NOK
1997   SEK
273   CHF

Product name : Caspase-4, human recombinant CASP4 Human

Catalog number : 1084-25

Quantity: 25 units

Availability: Yes

Supplier name : Biovis

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About this Product :

Caspase-4, human recombinant CASP4 Human recombinant proteins Most stable storage is at - 81 C or lower but some lyophilised proteins can be stored at +4C. Please read carefully the data sheet of the Caspase-4, human recombinant CASP4 Human.
http://mybiofast.com/ver.php?search=rec.&submit=Search

Caspase-4, human recombinant CASP4 Human Human samples 80 % of the research is conducted on human samples. Gentaur suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as Caspase-4, human recombinant CASP4 Human.
http://mybiofast.com/ver.php?search=human+&submit=Search

More Details about

Alternate Names / Synonyms: Active Human Caspase-4, Active Caspase-4, Caspase-4 Enzyme, Recombinant caspase-4, human caspase-4, human caspases, active caspases

Gene Symbol: CASP4

Accession #: P49662

Gene ID: 837

Source: E. Coli.

Appearance: Lyophilized powder

Physical Form Description: Lyophilized powder

Molecular Weight: N/A

Purity by SDS-PAGE: ≥95%

Purity by HPLC: N/A

Endotoxin Level: N/A

Biological Activity: > 5000 units/mg

Reconstitution Instructions: Reconstitute to 1 unit per µl in PBS containing 15% glycerol.

Storage Temp.: -70°C

Shipping: gel pack

Background Information: Caspase-4 (also know as Ich-4, ICErelII, TX) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-4 exists in cells as an inactive proenzyme which is matured by proteolysis to yield large and small subunits. The active caspase-4 is a heterotetramer consisting of two large and two small subunits. To date the mechanism of caspase-4 activation and roles of caspase-4 in apoptosis are poorly understood. The recombinant active human caspase-4 was expressed in E. coli. The active caspase-4 is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-WEHD-pNA (Cat. #1102-200) or Ac-WEHD-AFC (1101-200).

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans.

 

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Pathways :
WP1772: Apoptosis Modulation and Signaling
WP2107: pathways in human cancer
WP1018: Apoptosis
WP104: Alanine and aspartate metabolism
WP106: Alanine and aspartate metabolism
WP1126: Tryptophan metabolism
WP1137: Apoptosis
WP1254: Apoptosis
WP1290: Apoptosis
WP1329: Alpha6-Beta4 Integrin Signaling Pathway
WP1348: Androgen Receptor Signaling Pathway
WP1351: Apoptosis
WP1381: G13 Signaling Pathway
WP1530: miRNA regulation of DNA Damage Response
WP1545: miRNAs involved in DDR
WP1965: VEGF-receptor Signal Transduction
WP2085: miRNAs involved in DDR
WP2087: miRNA regulation of DNA Damage Response
WP2316: PPAR signaling pathway
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP2353: vitamin B9 (folate) biosynthesis pathway
WP2359: Parkin-Ubiquitin Proteasomal System pathway
WP240: Alanine and aspartate metabolism
WP254: Apoptosis
WP270: Tryptophan metabolism

Related Genes :
[CASP4 ICH2] Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit 1; Caspase-4 subunit 2]
[Casp4 Casp11 Caspl Ich3] Caspase-4 (CASP-4) (EC 3.4.22.64) (Caspase-11) (CASP-11) (Protease ICH-3) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
[CASP4] Caspase-4 (CASP-4) (EC 3.4.22.57) [Cleaved into: Caspase-4 subunit 1; Caspase-4 subunit 2]
[CARD16 COP COP1] Caspase recruitment domain-containing protein 16 (Caspase recruitment domain-only protein 1) (CARD-only protein 1) (Caspase-1 inhibitor COP) (Pseudo interleukin-1 beta converting enzyme) (Pseudo-ICE) (Pseudo-IL1B-converting enzyme)
[CASP8 MCH5] Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[CASP4 At5g06200 MBL20.8] Casparian strip membrane protein 4 (AtCASP4)
[GSDMD DFNA5L GSDMDC1 FKSG10] Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT); Gasdermin-D, C-terminal (GSDMD-CT)]
[NOD2 CARD15 IBD1] Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1)
[APBB1 FE65 RIR] Amyloid-beta A4 precursor protein-binding family B member 1 (Protein Fe65)
[NLRP6 NALP6 PYPAF5] NACHT, LRR and PYD domains-containing protein 6 (Angiotensin II/vasopressin receptor) (PYRIN-containing APAF1-like protein 5)
[NLRP3 C1orf7 CIAS1 NALP3 PYPAF1] NACHT, LRR and PYD domains-containing protein 3 (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)
[TSHZ3 KIAA1474 TSH3 ZNF537] Teashirt homolog 3 (Zinc finger protein 537)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Nlrp1a Card7 Nalp1 Nalp1a Nlrp1] NACHT, LRR and PYD domains-containing protein 1a (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain)
[COI] Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Fragment)
[DDIT3 CHOP CHOP10 GADD153] DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153)
[Casp8] Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[Casp8] Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[CGAS C6orf150 MB21D1] Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1)
[TMEM214 PP446] Transmembrane protein 214
[Casp4] Caspase 4
[Gsdmdc1 Gsdmd] Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT); Gasdermin-D, C-terminal (GSDMD-CT)]
[RNF34] E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34)
[Nlrp1b Nalp1b] NACHT, LRR and PYD domains-containing protein 1b allele 4
[Apbb1 Fe65] Amyloid-beta A4 precursor protein-binding family B member 1 (Protein Fe65)
[Nlrp1b Nalp1b] NACHT, LRR and PYD domains-containing protein 1b allele 1
[CASP3 CPP32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP4 CK820_G0031100] CASP4 isoform 2 (Caspase 4, apoptosis-related cysteine peptidase)
[Nlrp1b Nalp1b] NACHT, LRR and PYD domains-containing protein 1b allele 3
[Nlrp3 Cias1 Mmig1 Nalp3 Pypaf1] NACHT, LRR and PYD domains-containing protein 3 (Cold autoinflammatory syndrome 1 protein homolog) (Cryopyrin) (Mast cell maturation-associated-inducible protein 1) (PYRIN-containing APAF1-like protein 1)

Bibliography :
[28409545] High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles.
[26427658] The effect of bovine rotavirus and its nonstructural protein 4 on ER stress-mediated apoptosis in HeLa and HT-29 cells.
[21282934] Caspase-4 directly activates caspase-9 in endoplasmic reticulum stress-induced apoptosis in SH-SY5Y cells.
[20514521] TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4.
[18182481] OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells.
[16183649] Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response.
[15326478] A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.
[12597888] A bicistronic expression system for bacterial production of authentic human interleukin-18.
[10477277] Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9.