Product name : Autoimmune diseases: RNP _ Sm IgG,ELISA kit
Catalog number : BQ 038G
Quantity: 96 tests
Supplier name : Bioquant
Data sheet : Ask more or other datasheet now !
|Quantity||96 Well Plate|
|Sample Type||Serum or Plasma|
The RNP/Sm IgG ELISA test system is an enzyme linked immunosorbent assay (ELISA) for the detection of IgG class antibodies to RNP-Sm in human serum or plasma. Systemic autoimmune disease is characterized by the presence of circulating auto-antibodies directed to a wide variety of cellular antigens. Systemic lupus erythematosis (SLE), commonly referred to as Lupus is the best known of these diseases. Other possible connective tissue diseases include mixed connective tissue disease (MCTD), Sjogren syndrome, sclerodema, and polymyositis/dermatomyositis. The majority can be diagnosed by clinical presentation and their antibody profiles to the various antigens involved, which include dsDNA, Sm, RNP, Ro, La Scl-70, Jo1 and Histones. Therefore, immunoassays for autoantibodies are useful for diagnostic and prognostic evaluations of autoimmune disease. RNP Abs target U1 RNA 70kD, A or C proteins and are present in most MCTD patients and in about 15% of SLE patients. The Sm or Smith Abs target B’/B or D proteins and are present in approximately 30% of patients with SLE . Sm is a very specific marker for SLE. Sm antibodies are very rare in other autoimmune diseases and normals.
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