Product name : Anti CEL Monoclonal Antibody (KNH-30)
Catalog number : 300-09971
Supplier name : BBridge
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Reaction of protein amino groups with glucose leads, through the early products such as a Schiff base and Amadori rearrangement products, to the formation of advanced glycation end products (AGEs). Recent immunological studies using anti-AGEs antibody (6D12) demonstrated the presence of AGEs-modified proteins in several human tissues: human lens (nondiabetic and noncataractous), renal proximal tubules in patients with diabetic nephropathy and chronic renal failure, diabetic retina, peripheral nerves of diabetic neuropathy, atherosclerotic lesions of arterial walls, 2-microglobulin forming amyloid fibrils in patients with hemodialysis-related amyloidosis, senile plaques of patients with Alzheimer’s disease, the peritoneum of CAPD patients, skin elastin in actinic elastosis, and ceriod/lipofuscin deposits. These results suggest a potential role of AGEs-modification in normal aging as well as age-enhanced disease processes.
This antibody named as 6D12 has been used to demonstrate AGEs-modified proteins in these human tissues, indicating potential usefulness of this antibody for histochemical identification and biochemical quantification of AGEs-modified proteins.
CEL is known to generate from protein modification by methylglyoxal . Mclellan et al. demonstrated that
plasma methylglyoxal, which is believed to be generate from Embden-Meyerhof and polyol pathways,
concentrations in insulin-dependent diabetic patients were about 7-times higher than those of normal individuals.
For examples, CEL was identified in human lens proteins at a concentration similar to that of CML and its accumulation increased with age like CML, indicating that CEL may play an important marker for aging and age-dependent disease such as diabetic complications.
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