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Index / BPS Bioscience / Wnt Signaling Pathway TCF-LEF reporter-HEK293 stable cell line /Product Detail : 60501 Wnt Signaling Pathway TCF-LEF reporter-HEK293 stable cell line
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Wnt Signaling Pathway TCF-LEF reporter-HEK293 stable cell line

 Price: 3168   EUR
3595   USD
2457   GBP

Product name : Wnt Signaling Pathway TCF-LEF reporter-HEK293 stable cell line

Catalog number : 60501

Quantity: 2 vials

Availability: Yes

Supplier name : BPS Bioscience

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More Details about

Background
The Wnt Signaling Pathway TCF/LEF Reporter (Luc) – HEK293 Cell Line is designed for
monitoring the activity of the Wnt/b-catenin signaling pathway. The Wnt pathway controls
a large and diverse set of cell fate decisions in embryonic development, adult organ
maintenance and disease. Wnt proteins bind to receptors on the cell surface, initiating a
signaling cascade that leads to stabilization and nuclear translocation of b-catenin. b-
catenin then binds to TCF/LEF transcription factors in the nucleus, leading to
transcription and expression of Wnt-responsive genes.
Description
The Wnt Signaling Pathway TCF/LEF Reporter (Luc) – HEK293 Cell Line contains a
firefly luciferase gene under the control of TCF/LEF responsive elements stably
integrated into HEK293 cells. This cell line is validated for the response to the
stimulation of mouse Wnt3a and to the treatment with an inhibitor of Wnt/b-catenin
signaling pathway.
Application
• Monitor Wnt signaling pathway activity.
• Screen activators or inhibitors of Wnt / b-catenin signaling pathway.
Format
Each vial contains ~1.5 X 106 cells in 1 ml of 10% DMSO.

References
1. Clevers H (2006) Wnt/beta-catenin signaling in development and disease. Cell
127(3):469-480.
2. Chen B et al. (2009) Small molecule-mediated disruption of Wnt-dependent signaling in
tissue regeneration and cancer. Nature Chemical Biology 5(2):100-107.

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