More Details about
AlbuVoid™ Albumin Depletion Kit
Albumin Depletion Plus Low Abundance Serum Protein Enrichment
Albumin voids in flow-through >95%, with <30 minute bind/wash/elute protocol
Low abundance enrichment equivalent or better than hexa-peptides or antibodies
Disposable, cost-effective, no column regeneration or cross-contamination
Mild elution maintains tertiary structure and simple transfer to secondary analysis
The eluted fractions retain their enzymatic and biological activity
Removes albumin from many species including human, sheep, bovine, goat, rat, and calf.
AlbuVoid™ is a albumin depletion reagent kit. It removes albumin from serum and plasma samples
while concentrating low abundance, and/or low molecular weight proteins. The AlbuVoid™ protocol
uses mild buffers; the protocol conditions are so gentle that native enzyme activity is retained in
elution fractions. AlbuVoid™ considerably enhances resolution of proteins below 50 kD, a limitation
of alternate enrichment protocols.
AlbuVoid does not bind albumin. All other proteins(except albumin) in the sample binds to AlbuVoid
and then you can elute off all the proteins minus the albumin. Resulting in low abundance serum
protein enrichment. It is ideal for applications involving biomarker discovery, enzyme assays,
toxicological studies for new drugs, protein profiling using SELDI analysis, protein array pixelation
,1D and 2D gel electrophoresis, LC/MS, and MALDI-TOF MS and cytokines research.
AlbuVoid™ derives from a silica-based library of individual mixed-mode polymeric ligands. The
library was designed to facilitate weak binding of proteins, allowing for rapid elution from the matrix
without any foreknowledge of the variety of proteins contained in the starting sample. Because of its
specific binding properties, AlbuVoid™ depletes high abundance proteins in serum like albumin while
improving the resolution of less abundant serum proteins.
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