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Index / Trevigen / Stem Cell Rat Mesenchymal Cells /Product Detail : 5000-001-01 Stem Cell Rat Mesenchymal Cells
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#5000-001-01 Stem Cell Rat Mesenchymal Cells

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  Price : 108   EUR
122   USD
83   GBP
453   Zloty
14457   JPY
833   NOK
892   SEK
122   CHF

Product name : Stem Cell Rat Mesenchymal Cells

Catalog number : 5000-001-01

Quantity: 1 vial

Availability: Yes

Supplier name : Trevigen

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More Details about

Cultrex Rat Mesenchymal Cells
Catalog #: 5000-001-01


Rat Mesenchymal Stem Cells

Mesenchymal Stem Cells (MSC), also known as marrow stromal cells, are a self-renewing population of multipotent cells present in bone marrow and many other adult tissues. MSC can be isolated from bone marrow by adherence to plastic, and can differentiate into multiple lineage- specific cells that form bone, fat, cartilage, muscle, neuronal cells and tendon. Due to their multilineage potential, they can be useful tools for a wide range of therapeutic and basic research, including transplantation studies and studies examining the repair of cardiac tissue, bone, cartilage, and tendons often using 3-D matrices. The generation of dependable information that can be shared between laboratories requires a consistent, highly purified source of MSC that have maintained their multipotency, as demonstrated by their ability to differentiate to different tissue types. Isolation of MSC is both a time and resource consuming process which can now be eliminated. A readily available and qualified source of cells will substantially decrease MSC preparation time required prior to experimentation.

Trevigen's RMSC are provided as a frozen ampoule containing 1 x 106 passage 3 cells that are greater than 99% pure. These cells can be maintained in an undifferentiated state when grown in Trevigen's qualified RMSC Medium supplemented with RMSC qualified FBS or induced to differentiate into adipogenic or osteogenic phenotype when growth media are supplemented with reagents contained in Trevigen's differentiation kits. Trevigen's RMSC can undergo 10 doublings without alteration in cell morphology or differentiation potential.

FEATURES:

  • Primary Mesenchymal Stem Cells isolated and purified from Rat Bone Marrow.
  • Qualified medium and fetal bovine serum to support undifferentiated growth of rat mesenchymal stem cells.

APPLICATIONS :

Therapeutic and basic research, including transplantation studies and studies examining the repair of cardiac tissue, bone, cartilage, and tendons often using 3-D matrices.

STORAGE:

Cultrex® Rat Mesenchymal Stem Cell Liquid Nitrogen

REFERENCES:

1. Phinney DG, Prockop DJ. 2007. Concise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Models of Tissue Repair-Current Views. Stem Cells 25:2896-2902.
2. Kolf CM, Cho E, Tuan RS. 2007. Biology of Adult Mesenchymal Stem Cells: Regulation of Niche, Self-Renewal and Differentiation. Arthritis Research and Therapy 9:204.
3. Javazon EH, Colter DC, Schwarz EJ, Prockop DJ. 2001. Rat Marrow Stromal Cells are More Sensative to Plating Density and Expand More Rapidly from Single-Cell-Derived Colonies than Human Marrow Stromal Cells. Stem Cells 19:219-225.
4. Li Yi, McIntosh K, Chen J, Zhang C, Gao, Q, Borneman J, Ragniski K, Mitchell J, Shen L, Zhang J, Lu D, Chopp M. 2006. Allogeneic bone marrow stromal cells promote glial-axonal remodeling without immunologic sensitization after stroke in rats. Experimental Neurology 198:313-25.

 

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Pathways :
WP1011: T Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1043: Calcium Regulation in the Cardiac Cell
WP1069: Integrin-mediated cell adhesion
WP1078: G1 to S cell cycle control
WP1083: Cell cycle
WP1130: T Cell Receptor Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1159: Calcium Regulation in the Cardiac Cell
WP1185: Integrin-mediated cell adhesion
WP1195: G1 to S cell cycle control
WP1200: Cell cycle
WP1345: T Cell Receptor Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP1365: Calcium Regulation in the Cardiac Cell
WP1386: Integrin-mediated cell adhesion
WP1393: Cell cycle
WP1411: Cell Division: First embryonic mitosis
WP1603: Nicotine Activity on Chromaffin Cells
WP1775: Cell Cycle Checkpoints
WP1782: APC/C-mediated degradation of cell cycle proteins
WP179: Cell cycle
WP1792: Cell Cycle, Mitotic
WP1793: Cell junction organization
WP1794: Cell surface interactions at the vascular wall

Related Genes :
[Kitlg Kitl Mgf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[Grem1 Cktsf1b1 Drm] Gremlin-1 (Cysteine knot superfamily 1, BMP antagonist 1) (Down-regulated in Mos-transformed cells protein)
[Pdpn] Podoplanin (E11 antigen epitope) (RTI140) (T1-alpha) (T1A) (Type I cell 40 kDa protein)
[Alcam] CD166 antigen (Activated leukocyte cell adhesion molecule) (HB2) (KG-CAM) (Protein MEMD) (SB-10 antigen) (CD antigen CD166)
[KIT SCFR] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
[KITLG MGF SCF] Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[Nfatc4 Nfat3] Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3)
[Cxcr4 Cmkar4] C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (Fusin) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)
[Notch1] Neurogenic locus notch homolog protein 1 (Notch 1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
[Pdgfra] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a)
[Cacna1c Cach2 Cacn2 Cacnl1a1 Cchl1a1] Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Rat brain class C) (RBC) (Voltage-gated calcium channel subunit alpha Cav1.2)
[Smarca4 Baf190a Brg1 Snf2b Snf2l4] Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
[Cacna1d Cach3 Cacn4 Cacnl1a2 Cchl1a2] Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Rat brain class D) (RBD) (Voltage-gated calcium channel subunit alpha Cav1.3)
[Cacna1a Cach4 Cacn3 Cacnl1a4] Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Brain calcium channel I) (BI) (Calcium channel, L type, alpha-1 polypeptide, isoform 4) (Rat brain class A) (RBA-I) (Voltage-gated calcium channel subunit alpha Cav2.1)
[Apex1 Ape Apex Ref1] DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
[Ackr3 Cmkor1 Cxcr7 Rdc1] Atypical chemokine receptor 3 (C-X-C chemokine receptor type 7) (CXC-R7) (CXCR-7) (Chemokine orphan receptor 1) (G-protein coupled receptor RDC1 homolog) (RDC-1)
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Ceacam1] Carcinoembryonic antigen-related cell adhesion molecule 1 (ATP-dependent taurocolate-carrier protein) (Cell-CAM 105) (C-CAM 105) (Ecto-ATPase) (GP110) (pp120) (CD antigen CD66a)
[Havcr2 Tim3 Timd3] Hepatitis A virus cellular receptor 2 homolog (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
[Gsk3b] Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Factor A) (FA) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
[Cdk2 Cdkn2] Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2)
[Ptprq Ptpgmc1] Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1) (rPTP-GMC1) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48)
[Ptprn] Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (105 kDa islet cell antigen) (BEM-3) (Brain-enriched membrane-associated protein tyrosine phosphatase) (ICA105) (ICA512) (PTP IA-2) (PTPLP) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]
[Aqp1 Chip28] Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Water channel protein for red blood cells and kidney proximal tubule)
[Kit Sl] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[TAL1 BHLHA17 SCL TCL5] T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5)
[Loxl2] Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2)
[Trim28 Kap1 Tif1b] Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (Nuclear corepressor KAP-1) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
[FLT3 CD135 FLK2 STK1] Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
[Kcnh1 Eag] Potassium voltage-gated channel subfamily H member 1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (EAG1) (r-eag) (Voltage-gated potassium channel subunit Kv10.1)

Bibliography :
[30878447] Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration.
[30878213] Calcimimetics maintain bone turnover in uremic rats despite the concomitant decrease in parathyroid hormone concentration.
[30876457] Calpain inhibitor MDL28170 improves the transplantation-mediated therapeutic effect of bone marrow-derived mesenchymal stem cells following traumatic brain injury.
[30875363] Abdominal Aortic Transplantation of Bone Marrow Mesenchymal Stem Cells Regulates the Expression of Ciliary Neurotrophic Factor and Inflammatory Cytokines in a Rat Model of Spinal Cord Ischemia-Reperfusion Injury.
[30870158] Extracellular Vesicles from Interferon-γ-primed Human Umbilical Cord Mesenchymal Stromal Cells Reduce Escherichia coli-induced Acute Lung Injury in Rats.
[30867820] Microporous polysaccharide multilayer coated BCP composite scaffolds with immobilised calcitriol promote osteoporotic bone regeneration both in vitro and in vivo.
[30867709] Efficacy of bone marrow mesenchymal stem cell transplantation in animal models of pulmonary fibrosis after exposure to bleomycin: A meta-analysis.
[30867070] HMGB1-modified mesenchymal stem cells attenuate radiation-induced vascular injury possibly via their high motility and facilitation of endothelial differentiation.
[30867050] Human mesenchymal stem cells improve rat islet functionality under cytokine stress with combined upregulation of heme oxygenase-1 and ferritin.
[30867048] Efficient generation of male germ-like cells derived during co-culturing of adipose-derived mesenchymal stem cells with Sertoli cells under retinoic acid and testosterone induction.