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Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Related products :

Catalog number Product name Quantity
orb60223 Irinotecan Irinotecan (Camptosar, Campto, CPT-11) is a topoisomerase I inhibitor with an IC50 of 15.8 and 5.17 100 mg
100286-90-6 Irinotecan hydrochloride trihydrate Irinotecan HCl 3H2O 1g
orb61345 Irinotecan Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). Fo 500 mg
orb61044 Irinotecan, Hydrochloride Salt, Trihydrate Irinotecan, Hydrochloride Salt, Trihydrate For research use only. 100 mg
CS-1004-03 miRNA Pathway Profiling Cell Array (Notch Pathway, 4 Plates) 4 X 96
CS-1004-02 miRNA Pathway Profiling Cell Array (NFkB Pathway, 4 Plates) 4 X 96
CS-1003-03 miRNA Pathway Profiling Cell Array (Notch Pathway, 8 Plates) 8 X 96
CS-1004-05 miRNA Pathway Profiling Cell Array (Wnt b-catenin Pathway, 4 Plates) 4 X 96
CS-1003-04 miRNA Pathway Profiling Cell Array (MAPK Ras Pathway, 8 Plates) 8 X 96
CS-1003-05 miRNA Pathway Profiling Cell Array (Wnt b-catenin Pathway, 8 Plates) 8 X 96
CS-1003-02 miRNA Pathway Profiling Cell Array (NFkB Pathway, 8 Plates) 8 X 96
CS-1004-04 miRNA Pathway Profiling Cell Array (MAPK Ras Pathway, 4 Plates) 4 X 96
CS-1003-01 miRNA Pathway Profiling Cell Array (TGFb Pathway, 8 Plates) 8 X 96
CS-1004-01 miRNA Pathway Profiling Cell Array (TGFb Pathway, 4 Plates) 4 X 96
30-110 CBS is involved in the transsulfuration pathway. The first step of this pathway, from homocysteine to cystathionine, is catalyzed by this protein. CBS deficiency can cause homocystinuria which affects 0.1 mg
30-188 Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC, one of the last enzymes in this pathway, converts phosphopan 0.1 mg
30-888 The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. CHKA is the initial enzyme in the sequence and may play a regulatory role. It also catalyzes the phosp 0.05 mg
SIH-243-50MG Irinotecan HCl Inhibitor
KI4337 Irinotecan 200mg
KI4336 Irinotecan 100mg
SIH-243-250MG Irinotecan HCl Inhibitor
97682-44-8 Irinotecan _ 1g
136572-09-3 Irinotecan Hcl _ 1g
1752-250 Irinotecan Hydrochloride 250 mg
1752-50 Irinotecan Hydrochloride 50 mg

Pathways :

WP1197: Irinotecan Pathway
WP1080: Irinotecan Pathway
WP475: Irinotecan Pathway
WP961: Irinotecan Pathway
WP124: Irinotecan Pathway
WP229: Irinotecan Pathway
WP417: Oxidative Branch of the Pentose Phosphate Pathway
WP1381: G13 Signaling Pathway
WP557: ACE Inhibitor Pathway
WP2018: RANKL/RANK Signaling Pathway
WP774: Kit Receptor Signaling Pathway
WP230: TGF Beta Signaling Pathway
WP1: Statin Pathway
WP1904: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
WP862: Wnt Signaling Pathway NetPath
WP1094: IL-6 Signaling Pathway
WP968: IL-5 Signaling Pathway
WP2428: the quecetin and apoptosis pathway
WP118: IL-7 Signaling Pathway
WP372: Beta Oxidation Meta Pathway
WP1348: Androgen Receptor Signaling Pathway
WP488: Alpha6-Beta4 Integrin Signaling Pathway
WP17: daf-2 or insulin signaling pathway
WP68: Androgen Receptor Signaling Pathway
WP215: noncanonical wnt pathway

Related Genes :
[UGT1A1 GNT1 UGT1] UDP-glucuronosyltransferase 1-1 (UDPGT 1-1) (UGT1*1) (UGT1-01) (UGT1.1) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 1) (hUG-BR1) (UDP-glucuronosyltransferase 1-A) (UGT-1A) (UGT1A) (UDP-glucuronosyltransferase 1A1)
[CYP3A4 CYP3A3] Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55)
[CYP3A7] Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (Cytochrome P450-HFLA) (P450HLp2)
[TFPI LACI TFPI1] Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI)
[CYP3A5] Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (Cytochrome P450-PCN3)
[CYP2B6] Cytochrome P450 2B6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIB6) (Cytochrome P450 IIB1)
[DUSP19 DUSP17 LMWDSP3 SKRP1] Dual specificity protein phosphatase 19 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase TS-DSP1) (Low molecular weight dual specificity phosphatase 3) (LMW-DSP3) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating phosphatase 1) (SAPK pathway-regulating phosphatase 1)
[GPS2] G protein pathway suppressor 2 (GPS-2)
[Gps2] G protein pathway suppressor 2 (GPS-2)
[WISP1 CCN4] WNT1-inducible-signaling pathway protein 1 (WISP-1) (CCN family member 4) (Wnt-1-induced secreted protein)
[Wisp1 Ccn4 Elm1] WNT1-inducible-signaling pathway protein 1 (WISP-1) (CCN family member 4) (ELM-1)
[Ecsit Sitpec] Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC)
[FEM1B F1AA KIAA0396] Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha)
[Fem1b F1aa Kiaa0396] Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha) (mt-Fem)
[SRM1 MTR1 PRP20 YGL097W] Guanine nucleotide exchange factor SRM1 (Pheromone response pathway component SRM1) (Pre-mRNA-processing protein 20) (Regulator of chromosome condensation) (Suppressor of receptor mutations 1) (mRNA transport protein 1)
[ECSIT] Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC)
[geoA] Geraniol dehydrogenase (GeDH) (EC 1.1.1.347) (Geraniol oxidation pathway protein A) (Perillyl-alcohol dehydrogenase) (EC 1.1.1.144)
[TFPI2] Tissue factor pathway inhibitor 2 (TFPI-2) (Placental protein 5) (PP5)
[VTE1 SXD1 At4g32770 F4D11.30] Tocopherol cyclase, chloroplastic (EC 5.5.1.24) (Sucrose export defective 1) (Vitamin E pathway gene 1 protein)
[Dusp19 Skrp1] Dual specificity protein phosphatase 19 (EC 3.1.3.16) (EC 3.1.3.48) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating phosphatase 1)
[ago1 csp9 SPCC736.11] Protein argonaute (Cell cycle control protein ago1) (Eukaryotic translation initiation factor 2C 2-like protein ago1) (PAZ Piwi domain protein ago1) (Protein slicer) (RNA interference pathway protein ago1)
[HPT1 TPT1 VTE2-1 At2g18950 F19F24.15] Homogentisate phytyltransferase 1, chloroplastic (AtHPT1) (EC 2.5.1.115) (Tocopherol polyprenyltransferase 1) (Vitamin E pathway gene 2-1 protein) (AtVTE2-1)
[EPS8L2 EPS8R2 PP13181] Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)
[dcr1 SPCC188.13c SPCC584.10c] Protein Dicer (Cell cycle control protein dcr1) (RNA interference pathway protein dcr1) [Includes: Endoribonuclease dcr1 (EC 3.1.26.-); ATP-dependent helicase dcr1 (EC 3.6.4.-)]
[ATP2C2 KIAA0703 SPCA2] Calcium-transporting ATPase type 2C member 2 (ATPase 2C2) (EC 7.2.2.10) (Secretory pathway Ca(2+)-ATPase 2)
[CCN6 WISP3 UNQ462/PRO790/PRO956] Cellular communication network factor 6 (CCN family member 6) (WNT1-inducible-signaling pathway protein 3) (WISP-3)
[Steap3 Tsap6] Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Protein nm1054) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6)
[STEAP3 TSAP6] Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde)
[SEPTIN4 ARTS PNUTL2 SEP4 SEPT4 hucep-7] Septin-4 (Apoptosis-related protein in the TGF-beta signaling pathway) (ARTS) (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Cerebral protein 7) (Peanut-like protein 2)
[EPS8L1 DRC3 EPS8R1 PP10566] Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1)

Bibliography :
[32036211] The role of single strand break repair pathways in cellular responses to camptothecin induced DNA damage.
[31981591] Overexpressed CES2 has prognostic value in CRC and knockdown CES2 reverses L-OHP-resistance in CRC cells by inhibition of the PI3K signaling pathway.
[31932471] Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.
[31889589] Cetuximab enhances the efficiency of irinotecan through simultaneously inhibiting the MAPK signaling and ABCG2 in colorectal cancer cells.
[31813002] Ganciclovir reduces irinotecan-induced intestinal toxicity by inhibiting NLRP3 activation.
[31705130] From state-of-the-art treatments to novel therapies for advanced-stage pancreatic cancer.
[31566309] Encorafenib, Binimetinib, and Cetuximab in V600E-Mutated Colorectal Cancer.
[31555951] Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways.
[31466383] Quantifying Risk Pathway Crosstalk Mediated by miRNA to Screen Precision drugs for Breast Cancer Patients.
[31444410] Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors.