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Type II diabetes mellitus

pathways : Type II diabetes mellitus pathways:

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Catalog number Product name Quantity
orb60627 Glipizide Glipizide(Glucotrol) is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. For research use only. 500 mg
NIDDM3 NIDDM1 Gene non-insulin-dependent diabetes mellitus (common, type 2) 1
NIDDM4 NIDDM2 Gene non-insulin-dependent diabetes mellitus (common, type 2) 2
orb60286 Acarbose Acarbose is an anti-diabetic drug used to treat type 2 diabetes mellitus and, in some countries, prediabetes. For research use only. 1 g
IDE IDDM9 Gene insulin-dependent diabetes mellitus 9
IDDM8 IDDM6 Gene insulin-dependent diabetes mellitus 6
IDDM18 IDDM16 Gene insulin-dependent diabetes mellitus 16
IDDM2 IDDM17 Gene insulin-dependent diabetes mellitus 17
IDDM23 IDDM18 Gene insulin-dependent diabetes mellitus 18
IDDM24 IDDM2 Gene insulin-dependent diabetes mellitus 2
IDDM6 IDDM3 Gene insulin-dependent diabetes mellitus 3
IDDMX IDDM8 Gene insulin-dependent diabetes mellitus 8
IDDM9 IDDM7 Gene insulin-dependent diabetes mellitus 7
IDDM7 IDDM4 Gene insulin-dependent diabetes mellitus 4
IDDM17 IDDM15 Gene insulin-dependent diabetes mellitus 15
IDDM16 IDDM14 Gene insulin-dependent diabetes mellitus 14
IDDM15 IDDM13 Gene insulin-dependent diabetes mellitus 13
IDDM13 IDDM10 Gene insulin-dependent diabetes mellitus 10
IDDM14 IDDM11 Gene insulin-dependent diabetes mellitus 11
orb60745 Metformin hydrochloride Metformin hydrochloride(Glucophage) is a biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. F 10 mg
JD1H2_R2S Diabetes type 1 (juvenil diabetes) ,JD1H2:2 SignArrays
JD1H1_F8S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1:8 SignArrays
JD1H1_F4S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1:4 SignArrays
JD1H1_R12S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1:12 SignArrays
JD1H1_R24S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1:24 SignArrays

Pathways :

WP1584: Type II diabetes mellitus
WP1017: Type II interferon signaling (IFNG)
WP1136: Type II interferon signaling (IFNG)
WP1253: Type II interferon signaling (IFNG)
WP1289: Type II interferon signaling (IFNG)
WP1350: Type II interferon signaling (IFNG)
WP1801: Diabetes pathways
WP2113: Type III interferon signaling
WP2272: Pathogenic Escherichia coli infection
WP585: Interferon type I
WP619: Type II interferon signaling (IFNG)
WP786: Type II interferon signaling (IFNG)
WP900: Type II interferon signaling (IFNG)

Related Genes :
[IAPP] Islet amyloid polypeptide (Amylin) (Diabetes-associated peptide) (DAP) (Insulinoma amyloid peptide)
[PEA15] Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED)
[GCK] Glucokinase (EC (Hexokinase type IV) (HK IV) (Hexokinase-4) (HK4) (Hexokinase-D)
[SLC2A4 GLUT4] Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)
[PTPRN2 KIAA0387] Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60]
[PTPRN ICA3 ICA512] Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]
[HNF1B TCF2] Hepatocyte nuclear factor 1-beta (HNF-1-beta) (HNF-1B) (Homeoprotein LFB3) (Transcription factor 2) (TCF-2) (Variant hepatic nuclear factor 1) (vHNF1)
[Cblb] E3 ubiquitin-protein ligase CBL-B (EC (Casitas B-lineage lymphoma proto-oncogene b) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
[Ptprn2] Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC (PTP IA-2beta) (Phogrin) (Protein tyrosine phosphatase-NP) (PTP-NP) [Cleaved into: IA-2beta71; IA-2beta64; IA-2beta60]
[PTGDS PDS] Prostaglandin-H2 D-isomerase (EC (Beta-trace protein) (Cerebrin-28) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS) (PGDS2)
[KCNJ11] ATP-sensitive inward rectifier potassium channel 11 (IKATP) (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11)
[INPPL1 SHIP2] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)
[HNF4A HNF4 NR2A1 TCF14] Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
[INSR] Insulin receptor (IR) (EC (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[botA atx bna bonT CLM_0897] Botulinum neurotoxin type A2 (BoNT/A) (Bontoxilysin-A) (BOTOX) [Cleaved into: Botulinum neurotoxin A2 light chain (LC) (EC; Botulinum neurotoxin A2 heavy chain (HC)]
[TCF7L2 TCF4] Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)
[AKT2] RAC-beta serine/threonine-protein kinase (EC (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC-PK-beta)
[MT-ND1 MTND1 NADH1 ND1] NADH-ubiquinone oxidoreductase chain 1 (EC (NADH dehydrogenase subunit 1)
[CDKAL1] Threonylcarbamoyladenosine tRNA methylthiotransferase (EC (CDK5 regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase)
[Slc2a4 Glut-4 Glut4] Solute carrier family 2, facilitated glucose transporter member 4 (GT2) (Glucose transporter type 4, insulin-responsive) (GLUT-4)
[PDX1 IPF1 STF1] Pancreas/duodenum homeobox protein 1 (PDX-1) (Glucose-sensitive factor) (GSF) (Insulin promoter factor 1) (IPF-1) (Insulin upstream factor 1) (IUF-1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1)
[INS] Insulin [Cleaved into: Insulin B chain; Insulin A chain]
[PAX4] Paired box protein Pax-4
[HNF1A TCF1] Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)
[ABCC8 HRINS SUR SUR1] ATP-binding cassette sub-family C member 8 (Sulfonylurea receptor 1)
[IRS1] Insulin receptor substrate 1 (IRS-1)
[ADIPOQ ACDC ACRP30 APM1 GBP28] Adiponectin (30 kDa adipocyte complement-related protein) (Adipocyte complement-related 30 kDa protein) (ACRP30) (Adipocyte, C1q and collagen domain-containing protein) (Adipose most abundant gene transcript 1 protein) (apM-1) (Gelatin-binding protein)
[SLC19A2 THT1 TRMA] Thiamine transporter 1 (ThTr-1) (ThTr1) (Solute carrier family 19 member 2) (Thiamine carrier 1) (TC1)
[ANGPTL8 C19orf80 RIFL UNQ599/PRO1185] Angiopoietin-like protein 8 (Betatrophin) (Lipasin) (Refeeding-induced fat and liver protein)
[KCNQ1 KCNA8 KCNA9 KVLQT1] Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1)

Bibliography :
[31004884] Emodin improves glucose metabolism by targeting microRNA-20b in insulin-resistant skeletal muscle.
[31004676] Efficacy and Safety of an Albiglutide Liquid Formulation Compared With the Lyophilized Formulation: A 26-Week Randomized, Double-Blind, Repeat-Dose Study in Patients With Type 2 Diabetes Mellitus.
[31004673] Circulating neuromedin U levels are similar in subjects with NGT and newly diagnosed T2DM and do not correlate with insulin secretion.
[31004672] Cardiac syncope recurrence in type 2 diabetes mellitus patients vs. normoglycemics patients: the CARVAS study.
[31004588] Do Third Molars Contribute to Systemic Inflammation? Results From a Population-Based Study From Northeast Germany.
[31004554] Photosafety of the Antidiabetic Drug Sitagliptin.
[31004325] Study Protocol for a Prospective, Multicenter, Randomized, Open-Label, Parallel-Group Clinical Trial Comparing the Efficacy and Safety of a Needle-Free Insulin Injector and a Conventional Insulin Pen in Controlling Blood Glucose Concentrations in Chinese Patients with Type 2 Diabetes Mellitus (The FREE Study).
[31004313] Serum levels of immunoglobulin G and complement 3 differentiate non-diabetic renal disease from diabetic nephropathy in patients with type 2 diabetes mellitus.
[31004310] Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes.
[31004282] Cardiovascular Risk in Type 1 Diabetes Mellitus.