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Pathways : WP1131: IL-7 Signaling PathwayWP908: B Cell Receptor Signaling PathwayWP1214: Notch Signaling PathwayWP29: Notch Signaling PathwayWP397: Id Signaling PathwayWP1449: Regulation of toll-like receptor signaling pathwayWP510: MAPK Signaling PathwayWP783: Androgen Receptor Signaling PathwayWP862: Wnt Signaling Pathway NetPathWP1161: TGF-beta Receptor Signaling PathwayWP358: MAPK signaling pathwayWP1366: ErbB signaling pathwayWP17: daf-2 or insulin signaling pathwayWP574: Hedgehog Signaling PathwayWP754: Wnt Signaling Pathway NetPathWP1037: p38 MAPK Signaling PathwayWP811: TNF-alpha NF-kB Signaling PathwayWP2118: Arrhythmogenic right ventricular cardiomyopathyWP1164: TGF Beta Signaling PathwayWP945: G13 Signaling PathwayWP364: IL-6 signaling pathwayWP1370: TGF Beta Signaling PathwayWP1044: ErbB signaling pathwayWP815: Id Signaling PathwayWP913: IL-3 Signaling Pathway Related Genes : [CCN4 WISP1] CCN family member 4 (WNT1-inducible-signaling pathway protein 1) (WISP-1) (Wnt-1-induced secreted protein) [Ecsit Sitpec] Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC) [Ccn4 Elm1 Wisp1] CCN family member 4 (ELM-1) (WNT1-inducible-signaling pathway protein 1) (WISP-1) [ECSIT] Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC) [TSHB] Thyrotropin subunit beta (Thyroid-stimulating hormone subunit beta) (TSH-B) (TSH-beta) (Thyrotropin beta chain) (Thyrotropin alfa) [CCN6 WISP3 UNQ462/PRO790/PRO956] Cellular communication network factor 6 (CCN family member 6) (WNT1-inducible-signaling pathway protein 3) (WISP-3) [TSHR LGR3] Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R) [Septin4 Arts Bh5 Gm11492 Pnut12 Sep4 Sept4] Septin-4 (Apoptosis-related protein in the TGF-beta signaling pathway) (Arts) (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Peanut-like protein 2) [tsh CG1374] Protein teashirt [cysC cysN TSH64_00635 TSH64_01890] Multifunctional fusion protein [Includes: Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) (ATP-sulfurylase large subunit) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (APS kinase) (ATP adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenosine-5'-phosphosulfate kinase)] [Tshr] Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R) [Tshr] Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R) [Ccn4 Elm1 Wisp1] CCN family member 4 (ELM-1) (WNT1-inducible-signaling pathway protein 1) (WISP-1) [cysC cysN TSH58p_17895] Multifunctional fusion protein [Includes: Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) (ATP-sulfurylase large subunit) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (APS kinase) (ATP adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenosine-5'-phosphosulfate kinase)] [tshr] Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R) [nnrE nnrD TSH58p_05965] Bifunctional NAD(P)H-hydrate repair enzyme (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6)] [nnrD nnrE TSH20_05665] Bifunctional NAD(P)H-hydrate repair enzyme (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6)] [nnrE nnrD TSH64_24690] Bifunctional NAD(P)H-hydrate repair enzyme (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6)] [CCN5 CT58 CTGFL WISP2 UNQ228/PRO261] CCN family member 5 (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58) (WNT1-inducible-signaling pathway protein 2) (WISP-2) [CGA] Glycoprotein hormones alpha chain (Anterior pituitary glycoprotein hormones common subunit alpha) (Choriogonadotropin alpha chain) (Chorionic gonadotrophin subunit alpha) (CG-alpha) (Follicle-stimulating hormone alpha chain) (FSH-alpha) (Follitropin alpha chain) (Luteinizing hormone alpha chain) (LSH-alpha) (Lutropin alpha chain) (Thyroid-stimulating hormone alpha chain) (TSH-alpha) (Thyrotropin alpha chain) [Dkk1 DKK1 Dkk1_predicted LOC100912050 NEWGENE_1307313 rCG_48380] Dickkopf WNT signaling pathway inhibitor 1 (Dickkopf homolog 1 (Xenopus laevis) (Predicted)) (Dickkopf-like protein 1) [apc] APC regulator of WNT signaling pathway [apc] APC regulator of WNT-signaling pathway [apc] APC regulator of WNT-signaling pathway [] APC regulator of WNT signaling pathway [APC] APC regulator of WNT signaling pathway (Adenomatous polyposis coli) [APC] APC regulator of WNT signaling pathway [dkk1b DKK1 dkk1] Dickkopf WNT-signaling pathway inhibitor 1b (Dickkopf-like protein 1) (Dickkopf1) [cysN cysC TSH20_21245] Multifunctional fusion protein [Includes: Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) (ATP-sulfurylase large subunit) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (APS kinase) (ATP adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenosine-5'-phosphosulfate kinase)] [glmU TSH58p_16910] Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)] Bibliography : [35468440] Acute nitrite exposure interferes with intestinal thyroid hormone homeostasis in grass carp (Ctenopharyngodon idellus).[35383535] Role of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway.[35219259] Cadmium induces testosterone synthesis disorder by testicular cell damage via TLR4/MAPK/NF-κB signaling pathway leading to reduced sexual behavior in piglets.[35140269] Sox9 is involved in the thyroid differentiation program and is regulated by crosstalk between TSH, TGFβ and thyroid transcription factors.[35101946] TSH-TSHR axis promotes tumor immune evasion.[35101570] Xiao-Luo-Wan treats propylthiouracil-induced goiter with hypothyroidism in rats through the PI3K-AKT/RAS pathways based on UPLC/MS and network pharmacology.[35093813] GLIS3 mediated by the Rap1/PI3K/AKT signal pathway facilitates real-ambient PM exposure disturbed thyroid hormone homeostasis regulation.[34970803] Tanycyte specific ablation of diacylglycerol lipase alpha stimulates the hypothalamic-pituitary-thyroid axis by decreasing the endocannabinoid mediated inhibition of TRH release.[34962261] Transcriptome-wide association study identifies multiple genes and pathways associated with thyroid function.[34896620] TSH stimulation of human thyroglobulin and thyroid peroxidase gene transcription is partially dependent on internalization.