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EGF Signaling in Vulval Development

pathways : EGF Signaling in Vulval Development pathways:

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Catalog number Product name Quantity
26-040 The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch protein family are transmembrane receptors that are critica 0.05 mg
27-307 PDPK1 phosphorylates and activates not only PKB_AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. It may play a general role in signaling processes and in development. 0.05 mg
27-698 CDX are homeodomain transcription factors related to the Drosophila caudal gene. The vertebrate CDX have been implicated in the development of the posterior embryo. Several signaling molecules, notabl 0.05 mg
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30-346 DKK1 is a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling 0.1 mg
25-680 WNT9B is a ligand for members of the frizzled family of seven transmembrane receptors. WNT9B is a probable developmental protein. WNT9B may be a signaling molecule which affects the development of dis 0.05 mg
25-434 RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region fo 0.05 mg
UV1001 Vulval disease spectrum (vulva cancer progression) tissue array, 46 cases_100 cores
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Pathways :

WP2220: Notch signaling in Vulval Development
WP2221: EGF Signaling in Vulval Development
WP1453: Vulval development
WP680: Vulval Development and SynMuv
WP10: IL-9 Signaling Pathway
WP1004: Kit Receptor Signaling Pathway
WP1010: Wnt Signaling Pathway and Pluripotency
WP1011: T Cell Receptor Signaling Pathway
WP1012: IL-7 Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP1016: Wnt Signaling Pathway
WP1017: Type II interferon signaling (IFNG)
WP1022: Hedgehog Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1029: Notch Signaling Pathway
WP1031: IL-3 Signaling Pathway
WP1037: p38 MAPK Signaling Pathway
WP1044: ErbB signaling pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1048: TGF Beta Signaling Pathway
WP1049: G Protein Signaling Pathways
WP1052: Id Signaling Pathway
WP1055: IL-4 signaling Pathway

Related Genes :
[HBEGF DTR DTS HEGFL] Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)]
[sqv-8 ZK1307.5] Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8 (EC 2.4.1.135) (Glucuronyl transferase I) (GlcAT-I) (Squashed vulva protein 8) (Vulval invagination protein sqv-8)
[Hbegf Dtr Hegfl] Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF)]
[HBEGF HEGFL] Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF)]
[Egf] Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor]
[lip-1 C05B10.1] Dual specificity protein phosphatase lip-1 (EC 3.1.3.16) (EC 3.1.3.48) (Lateral signaling-induced phosphatase 1) (Mitogen-activated protein kinase phosphatase lip-1) (MAP kinase phosphatase lip-1)
[lst-4 Y37A1B.2] Sorting nexin lst-4 (Lateral signaling target protein 4)
[Hbegf Dtr Hegfl] Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF)]
[pat-3 ZK1058.2] Integrin beta pat-3 (Paralyzed arrest at two-fold protein 3)
[EGFL7 MEGF7 UNQ187/PRO1449] Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)
[Egfl7 Megf7] Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)
[MEGF8 C19orf49 EGFL4 KIAA0817] Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4)
[Megf8 Egfl4] Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4)
[Egf] Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor]
[ADGRE1 EMR1 TM7LN3] Adhesion G protein-coupled receptor E1 (EGF-like module receptor 1) (EGF-like module-containing mucin-like hormone receptor-like 1) (EMR1 hormone receptor)
[CELSR2 CDHF10 EGFL2 KIAA0279 MEGF3] Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3)
[MESD KIAA0081 MESDC2 MESDM UNQ1911/PRO4369] LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development LRP chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein) (Renal carcinoma antigen NY-REN-61)
[CELSR3 CDHF11 EGFL1 FMI1 KIAA0812 MEGF2] Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2)
[lin-3 let-94 F36H1.4] Protein lin-3 (Abnormal cell lineage protein 3) (Lethal protein 94)
[Adgre1 Emr1 Gpf480] Adhesion G protein-coupled receptor E1 (Cell surface glycoprotein F4/80) (EGF-like module receptor 1) (EGF-like module-containing mucin-like hormone receptor-like 1) (EMR1 hormone receptor)
[Tek Hyk Tie-2 Tie2] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b)
[TEK TIE2 VMCM VMCM1] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)
[Mesd Mesdc2] LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein)
[lin-44 E01A2.3] Abnormal cell lineage protein 44 (Wnt protein)
[Dner Bet Bret] Delta and Notch-like epidermal growth factor-related receptor (Brain EGF repeat-containing transmembrane protein)
[Celsr1] Cadherin EGF LAG seven-pass G-type receptor 1
[let-23 kin-7 ZK1067.1] Receptor tyrosine-protein kinase let-23 (EC 2.7.10.1) (Lethal protein 23)
[TEK TIE-2 TIE2] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TIE-2) (CD antigen CD202b)
[EGF] Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor (Urogastrone)]
[ADGRE2 EMR2] Adhesion G protein-coupled receptor E2 (EGF-like module receptor 2) (EGF-like module-containing mucin-like hormone receptor-like 2) (CD antigen CD312)

Bibliography :
[30700527] Necessity and Contingency in Developmental Genetic Screens: EGF, Wnt and Semaphorin Pathways in Vulval Induction of the Nematode .
[30037804] Physiological Starvation Promotes Vulval Induction.
[29235987] Gene-free methodology for cell fate dynamics during development.
[28954762] Integration of EGFR and LIN-12/Notch Signaling by LIN-1/Elk1, the Cdk8 Kinase Module, and SUR-2/Med23 in Vulval Precursor Cell Fate Patterning in .
[28826819] A Real-Time Biosensor for ERK Activity Reveals Signaling Dynamics during C. elegans Cell Fate Specification.
[28220250] Differing roles for sur-2/MED23 in C. elegans and C. briggsae vulval development.
[28098310] A computational model predicts genetic nodes that allow switching between species-specific responses in a conserved signaling network.
[27588814] Evolution of New cis-Regulatory Motifs Required for Cell-Specific Gene Expression in Caenorhabditis.
[27475488] The C. elegans hox gene lin-39 controls cell cycle progression during vulval development.
[27207389] The SWI/SNF chromatin remodeling complex exerts both negative and positive control over LET-23/EGFR-dependent vulval induction in Caenorhabditis elegans.