GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Pubmed ID: 16115198
Publication Date: //

Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein.


Ligand-bound receptors of the Transforming Growth Factor-beta (TGF-beta) family promote the formation of complexes between Smad proteins that subsequently accumulate in the nucleus and interact there with other transcriptional regulators, leading to modulation of target gene expression. We identified a novel nuclear protein, Smicl, which binds to Smad proteins. Smicl and Smads cooperate and enhance TGF-beta mediated activation of a Smad-responsive reporter gene. A domain with five CCCH-type zinc fingers in Smicl is structurally and functionally, at least in vitro, similar to a domain in CPSF-30, the 30 kDa subunit of Cleavage and Polyadenylation Specificity Factor (CPSF). Like CPSF-30, Smicl can associate with some other CPSF subunits characterized previously. Its effect on the induction of a reporter gene for TGF-beta requires the cleavage/polyadenylation signal downstream of the coding sequence of that gene. Thus, Smicl is a novel protein that displays CPSF-30-like activities, interacts in the nucleus with activated Smads, and potentiates in TGF-beta stimulated cells Smad-dependent transcriptional responses, possibly in conjunction with the activity of CPSF complexes.
Authors: Collart Clara , Remacle Jacques E , Barabino Silvia , van Grunsven Leo A , Nelles Luc , Schellens Ann , Van de Putte Tom , Pype Stefan , Huylebroeck Danny , Verschueren Kristin ,

Reference:

  1. ncbi.nlm.nih.gov. [Last access //].

Related products :

Catalog number Product name Quantity
18-003-44209 Cleavage and polyadenylation specificity factor subunit 4 - Cleavage and polyadenylation specificity factor 30 kDa subunit; CPSF 30 kDa subunit; NS1 effector domain-binding protein 1; Neb-1; No arches 0.05 mg Aff Pur
18-003-43627 Cleavage and polyadenylation specificity factor subunit 6 - Cleavage and polyadenylation specificity factor 68 kDa subunit; CPSF 68 kDa subunit; Pre-mRNA cleavage factor Im 68 kDa subunit; Protein HPB 0.1 mg Protein A
EIAAB09127 CFIm59,Cleavage and polyadenylation specificity factor 59 kDa subunit,Cleavage and polyadenylation specificity factor subunit 7,CPSF 59 kDa subunit,CPSF7,Homo sapiens,Human,Pre-mRNA cleavage factor Im
EIAAB09123 CFIm68,CFIM68,Cleavage and polyadenylation specificity factor 68 kDa subunit,Cleavage and polyadenylation specificity factor subunit 6,CPSF 68 kDa subunit,CPSF6,Homo sapiens,Human,Pre-mRNA cleavage fa
EIAAB09112 Cleavage and polyadenylation specificity factor 73 kDa subunit,Cleavage and polyadenylation specificity factor subunit 3,CPSF 73 kDa subunit,CPSF3,CPSF73,Homo sapiens,Human,mRNA 3'-end-processing endo