GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Pubmed ID: 16691243
Publication Date: //

The SIRP family of receptors and immune regulation.

The immune system must be highly regulated to obtain optimal immune responses for the elimination of pathogens without causing undue side effects. This tight regulation involves complex interactions between membrane proteins on leukocytes. Members of the signal-regulatory protein (SIRP) family, which are expressed mainly by myeloid cells, provide one example of these regulatory membrane proteins. There are three SIRP-family genes that encode proteins that have similar extracellular regions but different signalling potentials, and are therefore known as 'paired receptors'. In this Review, we describe recent studies defining the ligands of the SIRP-family members, with particular emphasis on relating the molecular interactions of these proteins to their role in immune-cell regulation.
Authors: Barclay A Neil , Brown Marion H ,


  1. [Last access //].

Related products :

Catalog number Product name Quantity
26-179 Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activatin 0.05 mg
27-113 TUB functions in signal transduction from heterotrimeric G protein-coupled receptors. It could be involved in the hypothalamic regulation of body weight.This gene encodes a member of the Tubby family 0.05 mg
EIAAB38503 CD172 antigen-like family member B,Homo sapiens,Human,Signal-regulatory protein beta-2,Signal-regulatory protein gamma,SIRPB2,SIRP-b2,SIRP-beta-2,SIRPG,SIRP-gamma
25-105 ZFAT1 may be involved in transcriptional regulation. Overexpression of ZFAT1causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated. 0.05 mg
31-145 Receptors for the C-C chemokine family include CKR-I, CKR-2A, CKR-3, CKR-4, CKR- 5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration 0.1 mg