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Pubmed ID :22216197
Publication Date : //

The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia.


Nrf1 (nuclear factor-erythroid 2 p45 subunit-related factor 1) is a transcription factor mediating cellular responses to xenobiotic and pro-oxidant stress. Nrf1 regulates the transcription of many stress-related genes through the electrophile response elements (EpREs) located in their promoter regions. Despite its potential importance in human health, the mechanisms controlling Nrf1 have not been addressed fully.

Authors : Chepelev Nikolai L , Bennitz Joshua D , Huang Ting , McBride Skye , Willmore William G ,

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