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Pubmed ID: 24324267
Publication Date: 2013/12/09

Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-β signaling.


ZNF451 is a transcriptional cofactor localized to promyelocytic leukemia bodies. Here, we present evidence demonstrating that ZNF451 physically interacts with Smad3/4 and functionally inhibits TGF-β signaling. Increased expression of ZNF451 attenuates TGF-β-induced growth inhibitory and gene transcriptional responses, whereas depletion of ZNF451 enhances TGF-β responses. Mechanistically, ZNF451 blocks the ability of Smad3/4 to recruit p300 in response to TGF-β, which causes reduction of histone H3K9 acetylation on the promoters of TGF-β target genes. Taken together, ZNF451 acts as a transcriptional corepressor for Smad3/4 and negatively regulates TGF-β signaling.
Authors: Feng Yili , Wu Hongxing , Xu Yongxian , Zhang Zhengmao , Liu Ting , Lin Xia , Feng Xin-Hua ,

Reference:

  1. ncbi.nlm.nih.gov. [Last access 2013/12/09].

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