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Pubmed ID :26111475
Publication Date : //

Upregulation of Death Receptor 5 and Production of Reactive Oxygen Species Mediate Sensitization of PC-3 Prostate Cancer Cells to TRAIL Induced Apoptosis by Vitisin A.


Although Vitisin A, derived from wine grapes, is known to have cytotoxic, anti-adipogenic, anti-inflammatory and antioxidant effects, the underlying antitumor mechanism has not been investigated in prostate cancer cells to date. In the present study, the apoptotic mechanism of Vitisin A plus TNF-related apoptosis-inducing ligand (TRAIL) in prostate cancer cells was elucidated.

Authors : Shin Deokil , Kwon Hee-Young , Sohn Eun Jung , Nam Moon Sik , Kim Jung Hyo , Lee Jae Chul , Ryu Shi-Yong , Park Byungchun , Kim Sung-Hoon ,

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