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Pubmed ID :27014178
Publication Date : //

Lesion Size Is Exacerbated in Hypoxic Rats Whereas Hypoxia-Inducible Factor-1 Alpha and Vascular Endothelial Growth Factor Increase in Injured Normoxic Rats: A Prospective Cohort Study of Secondary Hypoxia in Focal Traumatic Brain Injury.


Hypoxia following traumatic brain injury (TBI) is a severe insult shown to exacerbate the pathophysiology, resulting in worse outcome. The aim of this study was to investigate the effects of a hypoxic insult in a focal TBI model by monitoring brain edema, lesion volume, serum biomarker levels, immune cell infiltration, as well as the expression of hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF).

Authors : Thelin Eric Peter , Frostell Arvid , Mulder Jan , Mitsios Nicholas , Damberg Peter , Aski Sahar Nikkhou , Risling Mårten , Svensson Mikael , Morganti-Kossmann Maria Cristina , Bellander Bo-Michael ,

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