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Pubmed ID :30885780
Publication Date : //

PPARD and Interferon Gamma Promote Transformation of Gastric Progenitor Cells and Tumorigenesis in Mice.


The peroxisome proliferator-activated receptor delta (PPARD) regulates cell metabolism, proliferation, and inflammation and has been associated with gastric and other cancers. Villin-positive epithelial cells are a small population of quiescent gastric progenitor cells. We expressed PPARD from a villin promoter to investigate the role of these cells and PPARD in development of gastric cancer.

Authors : Zuo Xiangsheng , Deguchi Yasunori , Xu Weiguo , Liu Yi , Li Haiyan S , Wei Daoyan , Tian Rui , Chen Weidong , Xu Min , Yang Yaying , Gao Shen , Jaoude Jonathan C , Liu Fuyao , Chrieki Sarah P , Moussalli Micheline J , Gagea Mihai , Sebastian Manu M , Zheng Xiaofeng , Tan Dongfeng , Broaddus Russell , Wang Jing , Ajami Nadim J , Swennes Alton G , Watowich Stephanie S , Shureiqi Imad ,

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