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Pubmed ID :31502378
Publication Date : //

Immunomodulatory effect of human bone marrow-derived mesenchymal stromal/stem cells on peripheral blood T cells from rheumatoid arthritis patients.


Rheumatoid arthritis (RA) is a Th1/Th17-mediated autoimmune whose current treatment, consisting in the blockage of inflammatory cytokines by disease-modifying anti-rheumatic drugs, is not effective for all patients. The therapeutic potential of mesenchymal stromal/stem cells (MSCs)' immunomodulatory properties is being explored in RA. Here, we investigate the effect of human bone marrow (BM)-MSCs on the expression of cytokines involved in RA physiopathology, by the distinct functional compartments of CD4 and CD8 T cells from RA patients.

Authors : Pedrosa Mónia , Gomes Joana , Laranjeira Paula , Duarte Cátia , Pedreiro Susana , Antunes Brígida , Ribeiro Tânia , Santos Francisco , Martinho António , Fardilha Margarida , Domingues M Rosário , Abecasis Manuel , P da Silva José António , Paiva Artur ,

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