GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Pubmed ID: 34551132
Publication Date: 2021/10/10

3-phosphoinositide-dependent protein kinase 1 (PDK1) mediates crosstalk between Src and Akt pathways in MET receptor signaling.

The high-affinity tyrosine kinase receptor MET plays a pivotal role in several facets of cell regulation. Although its mitogenic effect is well documented, some aspects of connection patterns between signaling pathways involved in cell cycle progression remain to be deciphered. We have used a tractable heterologous expression system, the Xenopus oocyte, to detect connections between distinct MET signaling cascades involved in G2/M progression. Our results reveal that Src acts as an adapter via its SH2 domain to recruit 3-phosphoinositide-dependent protein kinase 1 (PDK1) to the MET signaling complex leading to Akt phosphorylation. These data define an original crosstalk between Src and Akt signaling pathways that contributes to MET-induced entry into the M phase, and deserves further investigation in pathologies harboring deregulation of this receptor.
Authors: Molinaro Caroline , Martoriati Alain , Lescuyer Arlette , Fliniaux Ingrid , Tulasne David , Cailliau Katia ,


  1. [Last access 2021/10/10].

Related products :

Catalog number Product name Quantity
EIAAB30426 3-phosphoinositide-dependent protein kinase 1,Pdk1,Pdpk1,PkB kinase,Protein kinase B kinase,Rat,Rattus norvegicus
EIAAB30427 3-phosphoinositide-dependent protein kinase 1,Mouse,mPDK1,Mus musculus,Pdk1,Pdpk1
EIAAB30428 3-phosphoinositide-dependent protein kinase 1,Homo sapiens,hPDK1,Human,PDK1,PDPK1
31-010 CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fib 0.05 mg
26-436 SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably throu 0.05 mg