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Pubmed ID: 34846284
Publication Date: //

Genome-wide association study of gastric cancer- and duodenal ulcer-derived strains reveals discriminatory genetic variations and novel oncoprotein candidates.


Genome-wide association studies (GWASs) can reveal genetic variations associated with a phenotype in the absence of any hypothesis of candidate genes. The problem of false-positive sites linked with the responsible site might be bypassed in bacteria with a high homologous recombination rate, such as , which causes gastric cancer. We conducted a small-sample GWAS (125 gastric cancer cases and 115 controls) followed by prediction of gastric cancer and control (duodenal ulcer) strains. We identified 11 single nucleotide polymorphisms (eight amino acid changes) and three DNA motifs that, combined, allowed effective disease discrimination. They were often informative of the underlying molecular mechanisms, such as electric charge alteration at the ligand-binding pocket, alteration in subunit interaction, and mode-switching of DNA methylation. We also identified three novel virulence factors/oncoprotein candidates. These results provide both defined targets for further informatic and experimental analyses to gain insights into gastric cancer pathogenesis and a basis for identifying a set of biomarkers for distinguishing these -related diseases.
Authors: Tuan Vo Phuoc , Yahara Koji , Dung Ho Dang Quy , Binh Tran Thanh , Huu Tung Pham , Tri Tran Dinh , Thuan Ngo Phuong Minh , Khien Vu Van , Trang Tran Thi Huyen , Phuc Bui Hoang , Tshibangu-Kabamba Evariste , Matsumoto Takashi , Akada Junko , Suzuki Rumiko , Okimoto Tadayoshi , Kodama Masaaki , Murakami Kazunari , Yano Hirokazu , Fukuyo Masaki , Takahashi Noriko , Kato Mototsugu , Nishiumi Shin , Azuma Takashi , Ogura Yoshitoshi , Hayashi Tetsuya , Toyoda Atsushi , Kobayashi Ichizo , Yamaoka Yoshio ,

Reference:

  1. ncbi.nlm.nih.gov. [Last access //].

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