GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Pubmed ID: 36675101
Publication Date: 2023/01/13

Ginseng Sprouts Attenuate Mortality and Systemic Inflammation by Modulating TLR4/NF-κB Signaling in an LPS-Induced Mouse Model of Sepsis.


Sepsis leads to multi-organ failure due to aggressive systemic inflammation, which is one of the main causes of death clinically. This study aimed to evaluate whether ginseng sprout extracts (GSE) can rescue sepsis and explore its underlying mechanisms. C57BL/6J male mice ( = 15/group) were pre-administered with GSE (25, 50, and 100 mg/kg, ) for 5 days, and a single injection of lipopolysaccharide (LPS, 30 mg/kg, ) was administered to construct a sepsis model. Additionally, RAW264.7 cells were treated with LPS with/without GSE/its main components (Rd and Re) to explain the mechanisms corresponding to the animal-derived effects. LPS injection led to the death of all mice within 38 h, while GSE pretreatment delayed the time to death. GSE pretreatment also notably ameliorated LPS-induced systemic inflammation such as histological destruction in both the lung and liver, along with reductions in inflammatory cytokines, such as TNF-α, IL-6, and IL-1β, in both tissues and serum. Additionally, GSE markedly diminished the drastic secretion of nitric oxide (NO) by suppressing the expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) in both tissues. Similar changes in TNF-α, IL-1β, NO, iNOS, and COX2 were observed in LPS-stimulated RAW264.7 cells, and protein expression data and nuclear translocation assays suggested GSE could modulate LPS-binding protein (LBP), Toll-like receptor 4 (TLR4), and NF-κB. Ginsenoside Rd could be a major active component in GSE that produces the anti-sepsis effects. Our data support that ginseng sprouts could be used as an herbal resource to reduce the risk of sepsis. The corresponding mechanisms may involve TLR4/NF-κB signaling and a potentially active component.
Authors: Hwang Seung-Ju , Wang Jing-Hua , Lee Jin-Seok , Kang Ji-Yun , Baek Dong-Cheol , Kim Geon-Ho , Ahn Yo-Chan , Son Chang-Gue ,

Reference:

  1. ncbi.nlm.nih.gov. [Last access 2023/01/13].

Related products :

Catalog number Product name Quantity
EIAAB44148 Gene associated with retinoic and IFN-induced mortality 12 protein,Gene associated with retinoic and interferon-induced mortality 12 protein,GRIM12,GRIM-12,Homo sapiens,Human,KDRF,KM-102-derived reduc
EIAAB26732 Cell death regulatory protein GRIM-19,CI-B16.6,Complex I-B16.6,Gene associated with retinoic and IFN-induced mortality 19 protein,Gene associated with retinoic and interferon-induced mortality 19 prot
KMA094 Model of the portal systemic vein, 2 parts Set
KMA094 Model of the portal systemic vein, 2 parts, 360x175x530
EIAAB26734 CDA016,Cell death regulatory protein GRIM-19,CGI-39,CI-B16.6,Complex I-B16.6,Gene associated with retinoic and IFN-induced mortality 19 protein,Gene associated with retinoic and interferon-induced mor