GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Pubmed ID: 9076678
Publication Date: //

Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse.


We have cloned a mouse cDNA encoding a Mothers-against-dpp (MAD)-related protein, MADR1. Madr1 is ubiquitously expressed in the mouse embryo, indicating a broad function in a variety of tissue during embryogenesis, potentially relaying signals of numerous BMPs. However, its expression in the testis is strictly germ cell-specific and developmentally regulated. Testicular Madr1 expression starts in some seminiferous tubules at 2 weeks of age. After mid-puberty, a stage-specific Madr1 expression is established. During the cycling of the seminiferous epithelium, Madr1 expression initiates in the pachytene spermatocytes of stage V seminiferous tubules, peaks at stage X, then decreases as pachytene spermatocytes differentiate into secondary spermatocytes and then round spermatids. In the testis of adult Bmp8b homozygous mutant males, the Madr1- expressing pachytene spermatocytes are the first cell population to show increased apoptosis. These data suggest that MADR1 serves as a downstream component of the BMP8 signaling pathway during the differentiation of meiotic male germ cells.
Authors: Zhao G Q , Hogan B L ,

Reference:

  1. ncbi.nlm.nih.gov. [Last access //].

Related products :

Catalog number Product name Quantity
U0647m CLIA Dwarfin-A,Dwf-A,MAD homolog 1,Madh1,Madr1,Mad-related protein 1,mMad1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,Mothers-against-DPP-related 1,Mouse,Mus musculus,SMAD 96T
E0647m ELISA Dwarfin-A,Dwf-A,MAD homolog 1,Madh1,Madr1,Mad-related protein 1,mMad1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,Mothers-against-DPP-related 1,Mouse,Mus musculus,SMA 96T
E0647m ELISA kit Dwarfin-A,Dwf-A,MAD homolog 1,Madh1,Madr1,Mad-related protein 1,mMad1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,Mothers-against-DPP-related 1,Mouse,Mus musculu 96T
30-185 The GINS complex plays an essential role in the initiation of DNA replication. 0.1 mg
E0647h ELISA kit BSP1,BSP-1,Homo sapiens,hSMAD1,Human,JV4-1,MAD homolog 1,MADH1,MADR1,Mad-related protein 1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,SMAD 1,SMAD family member 96T