Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery
Publication Date : //
The multigene family encoding the five classes of replication-dependent histones has been identified from the human and mouse genome sequence. The large cluster of histone genes, HIST1, on human chromosome 6 (6p21-p22) contains 55 histone genes, and Hist1 on mouse chromosome 13 contains 51 histone genes. There are two smaller clusters on human chromosome 1: HIST2 (at 1q21), which contains six genes, and HIST3 (at 1q42), which contains three histone genes. Orthologous Hist2 and Hist3 clusters are present on mouse chromosomes 3 and 11, respectively. The organization of the human and mouse histone genes in the HIST1 cluster is essentially identical. All of the histone H1 genes are in HIST1, which is spread over about 2 Mb. There are two large gaps (>250 kb each) within this cluster where there are no histone genes, but many other genes. Each of the histone genes encodes an mRNA that ends in a stemloop followed by a purine-rich region that is complementary to the 5' end of U7 snRNA. In addition to the histone genes on these clusters, only two other genes containing the stem-loop sequence were identified, a histone H4 gene on human chromosome 12 (mouse chromosome 6) and the previously described H2a.X gene located on human chromosome 11. Each of the 14 histone H4 genes encodes the same protein, and there are only three histone H3 proteins encoded by the 12 histone H3 genes in each species. In contrast, both the mouse and human H2a and H2b proteins consist of at least 10 non-allelic variants, making the complexity of the histone protein complement significantly greater than previously thought.
Authors : Marzluff William F , Gongidi Preetam , Woods Keith R , Jin Jianping , Maltais Lois J ,
Related products :
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88
Logistic :0241 40 08 90 86
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
[email protected] | Gentaur | Gentaur
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123
Canada Montreal +15149077481
Ceská republika Praha +420246019719
Finland Helsset +358942419041
Magyarország Budapest +3619980547
US New York+17185132983
WP2366: Butyrate-induced histone acetylation
WP1502: Mitochondrial biogenesis
WP865: DNA Replication
WP1644: DNA replication
WP983: DNA Replication
WP1059: Diurnally regulated genes with circadian orthologs
WP273: Ovarian Infertility Genes
WP1175: Diurnally regulated genes with circadian orthologs
WP377: Genes of Meiotic Recombination
WP1678: Nucleotide excision repair
WP1898: Regulation of DNA replication
WP13: DNA Replication
WP466: DNA Replication
WP1379: Diurnally regulated genes with circadian orthologs
WP710: DNA damage response (only ATM dependent)
WP2290: RalA downstream regulated genes
WP2361: Gastric cancer network 1
WP150: DNA Replication
WP822: Diurnally regulated genes with circadian orthologs
WP1625: Base excision repair
WP941: Diurnally regulated genes with circadian orthologs
WP1003: Ovarian Infertility Genes
WP263: Ovarian Infertility Genes
WP34: Ovarian Infertility Genes
WP1676: Non-homologous end-joining
Related Genes :
 An integrated model for detecting significant chromatin interactions from high-resolution Hi-C data.
 A subset of replication-dependent histone mRNAs are expressed as polyadenylated RNAs in terminally differentiated tissues.
 Initiation and maintenance of pluripotency gene expression in the absence of cohesin.
 FLASH/casp8ap2 is indispensable for early embryogenesis but dispensable for proliferation and differentiation of ES cells.
 SMN is essential for the biogenesis of U7 small nuclear ribonucleoprotein and 3'-end formation of histone mRNAs.
 SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors.
 FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription.
 The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.
 FLASH degradation in response to UV-C results in histone locus bodies disruption and cell-cycle arrest.
 U2 snRNP binds intronless histone pre-mRNAs to facilitate U7-snRNP-dependent 3' end formation.
Enter catalog number :