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The nucleotide sequence of the 948,061 base pairs of chromosome XVI has been determined, completing the sequence of the yeast genome. Chromosome XVI was the last yeast chromosome identified, and some of the genes mapped early to it, such as GAL4, PEP4 and RAD1 (ref. 2) have played important roles in the development of yeast biology. The architecture of this final chromosome seems to be typical of the large yeast chromosomes, and shows large duplications with other yeast chromosomes. Chromosome XVI contains 487 potential protein-encoding genes, 17 tRNA genes and two small nuclear RNA genes; 27% of the genes have significant similarities to human gene products, and 48% are new and of unknown biological function. Systematic efforts to explore gene function have begun.
Authors : Bussey H , Storms R K , Ahmed A , Albermann K , Allen E , Ansorge W , Araujo R , Aparicio A , Barrell B , Badcock K , Benes V , Botstein D , Bowman S , Brückner M , Carpenter J , Cherry J M , Chung E , Churcher C , Coster F , Davis K , Davis R W , Dietrich F S , Delius H , DiPaolo T , Hani J ,
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WP1042: Nucleotide GPCRs
WP1158: Nucleotide GPCRs
WP1191: Nucleotide Metabolism
WP1364: Nucleotide GPCRs
WP146: Nucleotide Metabolism
WP1619: Amino sugar and nucleotide sugar metabolism
WP1678: Nucleotide excision repair
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WP207: Nucleotide GPCRs
WP2292: Chemokine signaling pathway
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